Below are collated results for the knockout stage of the 2012-13 CONCACAF Champions League. Ties are two-leg series, aggregate goals, away goals rule in effect unless the tie goes to extra time in the second leg. Winners of each round are highlighted in bold red lettering. First leg host is listed first, and first leg host's score is given first for both legs.
QUARTERFINALS (5-7 March 2013 / 12-14 March 2013)
QF1: Xelajú vs Monterrey
QF2: Houston Dynamo vs Santos Laguna
QF3: UANL vs Seattle Sounders
QF4: Herediano vs Los Angeles Galaxy
SEMIFINALS (2-4 April 2013 / 9-11 April 2013)
SF1: QF4 vs QF1
SF2: QF3 vs QF2
FINALS (24 April 2013 / 1 May 2013)
SF2 vs SF1